Representative Research

A Desulfurative Strategy for the Generation of Alkyl Radicals Enabled by Visible-Light Photoredox Catalysis

Fei Xue+, Falu Wang+, Jiazhen Liu, Jiamei Di, Qi Liao, Huifang Lu, Min Zhu, Liping He, Huan He, Dan Zhang, Hao Song, Xiao-Yu Liu, and Yong Qin*

Angew. Chem. Int. Ed. 2018, 57 (22), 6667–6671

We present a new desulfurative method for generating primary, secondary, and tertiary alkyl radicals through visible-light photoredox catalysis. A process that involves the generation of N-centered radicals from sulfonamide intermediates, followed by subsequent fragmentation, is critical to forming the corresponding alkyl radical species. This strategy has been successfully applied to conjugate addition reactions that features mild reaction conditions, broad substrate scope (>60 examples), and good functional-group tolerance.

Pre:Bioinspired Synthesis of (+)-Cinchonidine Using Cascade Reactions

Next:Review: Enabling syntheses of diterpenoid alkaloids and related diterpenes by an oxidative dearomatization/Diels–Alder cycloaddition strategy